A Probabilistic Approach to Description of Molecular Biological Processes on DNA and Their Object Oriented Simulation
From International Center for Computational Logic
A Probabilistic Approach to Description of Molecular Biological Processes on DNA and Their Object Oriented Simulation
U. HatnikU. Hatnik, Thomas HinzeThomas Hinze, Monika SturmMonika Sturm
U. Hatnik, Thomas Hinze, Monika Sturm
A Probabilistic Approach to Description of Molecular Biological Processes on DNA and Their Object Oriented Simulation
In V.V. Kluev and N.E. Mastorakis, eds., Proceedings WSES International Conference on Simulation (SIM2001), Malta, 2001
A Probabilistic Approach to Description of Molecular Biological Processes on DNA and Their Object Oriented Simulation
In V.V. Kluev and N.E. Mastorakis, eds., Proceedings WSES International Conference on Simulation (SIM2001), Malta, 2001
- KurzfassungAbstract
Inspired by the potential of DNA based recombination techniques, we have analyzed processes used in DNA computing at the molecular level in laboratory studies with the aim to specify these processes as detailed as possible. Based on this knowledge, we have developed a simulation tool of real occurring molecular biological processes considering side effects. Side effects are described by appropriate statistical parameters. The comparison of simulation results with real observations in the laboratory shows a high degree of accordance. Using the simulation tool, prognoses about resulting DNA strands and influences of side effects to subsequent DNA operations can be obtained. The number of strand duplicates reflecting DNA concentrations is considered as an important factor for a detailed description of the DNA computing operations on the molecular level in the simulation. This property allows to evaluate the quantitative balance of DNA concentrations in a test tube. The simulation considers the DNA based reactions and processes synthesis, annealing, melting, union, ligation, digestion, labeling, polymerisation, affinity purification, and gel electrophoresis. - Forschungsgruppe:Research Group: AutomatentheorieAutomata Theory
@inproceedings{ HatnikHinze+-SIM01-01,
author = {U. {Hatnik} and T. {Hinze} and M. {Sturm}},
booktitle = {Proceedings WSES International Conference on Simulation (SIM2001), Malta},
editor = {V.V. {Kluev} and N.E. {Mastorakis}},
title = {A Probabilistic Approach to Description of Molecular Biological Processes on DNA and Their Object Oriented Simulation},
year = {2001},
}
